To analyze the genotype-environment (G×E) interaction effects on the growth and survival traits of a rapid-growth strain of Crassostrea gigas, 28 full-sib families were constructed, and each family was divided into three groups, which were cultured in the Rushan, Rongcheng, and Huangdao Sea areas. The heritability and G×E effects on the growth and survival traits of 12-month-old C. gigas were estimated using a two-trait animal model and the REML method. The BLUP breeding value estimation method was used to comprehensively weigh the breeding values for shell height, body weight, and survival traits to screen for universal breeding materials. The results showed that the shell phenotypes of the strains found in the Rushan and Huangdao Sea areas were significantly better than those of the Rongcheng Sea area, which were more suitable for aquaculture. The heritability of growth and survival traits in the Rushan, Rongcheng, and Huangdao Sea areas were 0.16–0.62, 0.07–0.80, and 0.07–0.63, respectively. A scale effect was observed; however, in addition to the heritability of survival traits, they were all medium-high heritability and had good breeding potential. Therefore, the breeding effect was improved using the breeding value estimation method. Survival traits are mainly affected by environmental factors and can be directly selected based on the phenotype. Considering the different sea areas as fixed effects, the heritability of growth and survival traits, calculated by combining the three environments was 0.04–0.31. The decrease in comprehensive heritability indicated that environmental differences affected heritability assessment. In addition, the genetic correlation of the selected target traits between the two sea areas was less than 0.8, which indicated a significant G×E effect. Therefore, environmental factors must be considered comprehensively during breeding. By comparing the comprehensive breeding values, it was found that family G25 showed special adaptability to the Rushan Sea area, family G16 had special adaptability to the Rongcheng Sea area, and family G23 showed adaptability to the Rushan and Huangdao Sea areas, all of which showed significant gene rearrangement effects. Family G2 was found to have universal adaptability to the three sea area. The results obtained in this study provide an important reference for breeding a rapid-growth strain of the orange shell C. gigas.