PAE) family, is thought to have an endocrine disrupting effect on vertebrates and humans and has been identified as priority controlled hazardous substance in the United States and China. In order to evaluate the effect of DPB, we examined liver and gill levels of superoxide dismutase (SOD) and malondialdehyde (MDA), and brain levels of crimson snapper (DBP for respectively. The safe concentration (SC) of DBP was 2.04Gill superoxide dismutase (SOD) activity increased significantly as the concentration of DBP increased. In contrast, there was no clear pattern of induction or inhibition for liver SOD activity, though levels in the groups exposed to 0.5 were significantly different from the control ( was significantly higher after 6 h, but decreased thereafter. Similarly, increased then decreased, and. Brain levels of were 32.07%, 62.07%, and 61.60% higher in fish exposed to 0.125, , activity was lower in the treatment groups than in the control group after 96 h exposure (DBP on . It could be concluded that DBP causes oxidative stress and neurotoxicity in aquatic organisms. Thus, attention should be given to the potential ecological risk posed by this contaminant.