). esponse surface methodology (RSM) based on a two-factor Central Composite Rotatable Design (CCD) of experiments to optimize the level of these two factors within the range 18–37 and 0–16. The linear and quadratic effects of temperature and salinity had a significant effect on SGR and survival (). larval growth and survival increased then decreased with as temperature or salinity increased. In addition, the interaction between temperature and salinity had a significant effect on growth and survival (). SGR and survival were higher at 18–20 between salinities 5 and 7. In contrast, SGR and survival were higher at ~salinity 4 at between 35–37yielding values of 0.979 6 and 0.982 1 (), and had good predictive value. Temperature had a great influence on SGR survivalSolving the regression equation for temperature equal to 29.1and salinity equal to 5.4, the optimum predicted value for specific growth rate and survival is 10.08%∙d^{desirability is 0.973). Thus, our data suggest the growth and survival of tilapia larvae can be improved by rearing the species at an optimal combination of temperature and salinity}