yeast to complexes with thallus and extracellular bacterial . We investigated the effects of the antigen complexes on the cellular immune response of tilapia by. In addition, tHsp70 alone and its complexes significantly stimulated growth and attachment of peritoneal macrophages and enhanced of peritoneal macrophages.treatment with and led to cell death, while reduced the cell death. tHsp70 alone or tHsp70-antigen complexes significantly increased the expression of immune related genes () in tilapia peritoneal macrophages compared to antigen only and control groups. Our results suggest that tHsp70 has an immunoadjuvant and immunopotentiator function, and provides experimental data for development of a