We developed a method for evaluating the drug residue risk in fishery products. Using a power model, we applied common hypothesis-testing approaches and confidence interval criteria to assess the dose proportionality of ciprofloxacin (20 in the intestine, liver, plasma, and muscle tissue of Linn. The residue in the liver tissue was proportional to the initial dose but there was no relationship between initial dose and the residue in the intestine, plasma, and muscle. The fitting formula for AUC and dosage was =0.901). Our results suggest that the . Our method represents a novel approach to assessing the drug residue risk in fishery products.