A feeding trial was conducted to investigate G) with selenium (Se) and vitamin E (VE) on the growth performance, serum immune, and antioxidant indexes, and disease resistance of with an initial body weight of (0.83±0.02) g were randomly divided into 5 groups and fed one of five diets with added G, 300 mg/kg G+0.2 mg/kg Se+100 mg/kg VE, named G0, G1, G2, G3, and G4, respectively. After 35 d feeding, the shrimps were infected with white spot syndrome virus(WSSV).(WGR) was highest in G2, which was significantly higher than that of G1 by 6.4% (<0.05). Survival rate(SR) in G3 was significantly lower than in G0 and G1 (<0.05). Total hemocyte count (THC) activity increased significantly in G4 (<0.05) compared with G0.<0.05). Acidic phosphatase(ACP) activity in G3 was significantly lower than that in G4(<0.05). Alkaline phosphatase (AKP) activity in G2 was significantly higher than that in the other three treatment groups (<0.05). Glutathione peroxidase (GSH-PX) activity in G4 increased significantly compared with the other four groups (<0.05). There was no significant difference among the five groups in glutathione transferase (GST) activity (>0.05). Catalase (CAT) activity was highest in G1, being significantly higher than that in G2 and G4 (<0.05). The highest value of superoxide dismutase (SOD) activity was observed in G2, followed by G1 and G3. The former was significantly different compared with the other four groups (<0.05), and the latter two were increased significantly in comparison to G0 and G4 (<0.05). Malondialdehyde (MDA) content in G1, G2 and G4 decreased significantly compared with G0 and G3 (<0.05). ) radical activity in G1, G2, and G4 was significantly higher than that in G3 (<0.05). Compared with G1, total antioxidant (T-AOC) capacity in G3 increased significantly (<0.05). After 72 h of WSSV infection, the highest cumulative mortality rate (AMR) was observed in G0, AMR in G1–G4 were lower, with a significant decrease in G2 and G4 (<0.05).The relative percent survival (RPS) in these two groups was 30.8% and 26.9%, respectively. In conclusion, the combined addition of G+Se+VE might improve non-specific immunity, antioxidant capacity, and resistance to the white spot syndrome virus (WSSV) in .