Blood-brain barrier permeability and residual tissue characteristics of Avermectin(AVM) in Carassius auratus gibelio

Home > Archive>Volume 20, Issue 5, 2013 >1032-1038

Blood-brain barrier permeability and residual tissue characteristics of Avermectin(AVM) in Carassius auratus gibelio
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                        RUAN Jiming1RUAN Jiming1
1. Shanghai Ocean University, National Pathogen Collection Center for Aquatic Animals, Shanghai 201306, China;2. College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, China;3. Jiangxi Fisheries Research Institute, Ji
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1. Shanghai Ocean University, National Pathogen Collection Center for Aquatic Animals, Shanghai 201306, China;2. College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, China;3. Jiangxi Fisheries Research Institute, Ji
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HU Kun1HU Kun1
1. Shanghai Ocean University, National Pathogen Collection Center for Aquatic Animals, Shanghai 201306, China;2. College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, China;3. Jiangxi Fisheries Research Institute, Ji
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YANG Xianle1YANG Xianle1
1. Shanghai Ocean University, National Pathogen Collection Center for Aquatic Animals, Shanghai 201306, China;2. College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, China;3. Jiangxi Fisheries Research Institute, Ji
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ZHANG Haixin3ZHANG Haixin3
1. Shanghai Ocean University, National Pathogen Collection Center for Aquatic Animals, Shanghai 201306, China;2. College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, China;3. Jiangxi Fisheries Research Institute, Ji
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WANG Yi1WANG Yi1
1. Shanghai Ocean University, National Pathogen Collection Center for Aquatic Animals, Shanghai 201306, China;2. College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, China;3. Jiangxi Fisheries Research Institute, Ji
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ZHOU Ailing1ZHOU Ailing1
1. Shanghai Ocean University, National Pathogen Collection Center for Aquatic Animals, Shanghai 201306, China;2. College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, China;3. Jiangxi Fisheries Research Institute, Ji
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ZHAO Yini1ZHAO Yini1
1. Shanghai Ocean University, National Pathogen Collection Center for Aquatic Animals, Shanghai 201306, China;2. College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, China;3. Jiangxi Fisheries Research Institute, Ji
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Affiliation:1. Shanghai Ocean University, National Pathogen Collection Center for Aquatic Animals, Shanghai 201306, China;2. College of Animal Sciences and Technology, Jiangxi Agricultural University, Nanchang 330045, China;3. Jiangxi Fisheries Research Institute, Ji
Clc Number:S941
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Abstract:

Using tissue homogenate and high performance liquid chromatography(HPLC) methods, the blood-brain barrier permeability and residual tissue characteristics in were examined under different Avermectin (AVM) concentrations. AVM was detected in the 50= 0.127 mg/L, 0.071 mg/L, and 0.039 mg/L)) at 24 h, 48 h, and 96 h, respectively and the safety concentration (SC: 0.003 9 mg/L). Significant differences in the brain AVM contents among the three median lethal concentrations were observed( [() μg/g]. The above results show that AVM can penetrate the blood-brain barrier into the brain under different concentrations. Furthermore, the brain AVM contents were positively correlated with initial drug concentration. In addition, the AVM concentration-time data in the brain, liver, kidney, and muscle were all in line with the non-compartmental method in the DAS 3.0 pharmacokinetics software under the safe concentration (0.0039 mg/L). The main pharmacokinetic parameters were as follows: (1) max: liver>kidney>muscle>brain; (3) : liver>brain>kidney>muscle; (4) AUC: liver>kidney> brain>muscles. The results of this paper provide references for future fish blood-brain barrier research, and AVM nerve toxicity mechanism investigations and its application in aquaculture.

Key words:Avermectin; tissue homogenate method; HPLC; blood-brain barrier; Carassius auratus gibelio

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阮记明,胡鲲,杨先乐,章海鑫,王祎,周爱玲,赵依妮. 异育银鲫体内阿维菌素血脑屏障渗透性及组织残留[J]. Jounal of Fishery Sciences of China, 2013,[volume_no](5):1032-1038

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Online: September 26,2013
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