We quantified the effects of inbreeding on growth, survival and the yield which related to survival of domesticated for the inclusion in selective breeding programs of the future. To make this assessment, we systematically bred six inbreeding generations with known parentage. During the production season, we assessed the growth, survival and yield, with One-Way ANOVA statistical analysis. inbreeding generation by every per 10% inbreeding coefficient increasing, the estimated inbreeding depression coefficient was –2.4%— –5.1% in overall carapace width, –0.8%— –3.5% in body weight, –34.4%— –69.9% in overall survival and –14.1%— –35.4% in the yield which related to survival. And compared with the F₁ inbreeding generation, the F₃ did not appear inbreeding depression phenomenon, no matter in growth, survival and the yield which related to survival, and F₂, F₄, F₅ and F₆ all appeared different degree of inbreeding depression compared with F₁ in growth, survival and the yield which related to survival, and had a high and significant effect between six inbreeding generations (<0.05). At the harvest time, we analyzed uniformity and found that the variation coefficient of F₆ inbreeding generation is the largest in six inbreeding generations, means the uniformity of F₆ inbreeding generation is the worst in six inbreeding generations, but the difference with other each generation is not significant (>0.05). The consistency in direction of the inbreeding depression coefficients for six generations lends to support to the hypothesis that inbreeding reduces growth, survival and the yield which related to survival, even though the coefficients were not statistically significant due to high variability among animals. These results suggest that inbreeding should be avoided in crab breeding programs.