cells (F-AH) were used as an antigen to immunize healthy) via intraperitoneal injection. Peripheral blood samples were collected from immunized and control iant salamanders at 1, 4, 7, 21 and 28 d post-immunization immuneresponses by counting and classifying blood cells, determining the phagocytic percentage and index and serum agglutinating antibody titers. Compared to the control group, the number of erythrocytes and leucocytes in the peripheral blood of immunized animals increased significantly at 4, 7 d post-immunization, and reached a maximum value of 7.83×10⁷/mL and 6.74×10⁶/mL The percentage of neutrophils reached a maximum value of % at 4 d post-immunization and the number of monocytes reached a maximum value of % at 7 d post-immunization. The phagocytic percentage and phagocytic index increased significantly.at 4 d post-immunization, respectively. The number of lymphocyte and the serum agglutinating antibody titers increased significantly, and peaked at resulted in a relative percent survival in the immunized group of 69%. The results from this study demonst rated that F-AH enhanced the immunity of the iant salamander by increasing the number of erythrocytes and leucocytes in peripheral blood, improving the activity of phagocytes, the serum agglutinating antibodytiter and providing