In this study, two scallops, , were used to investigate the possibility of intergeneric distant hybridization in scallops. Using as male parent, we established four experimental groups-an orthogonal group MH, a reciprocal group HM, an inbred group HH-to investigate the fertilization, early development, and growth and survival of reciprocal crosses between the two scallops. The results show that reciprocal crosses of can derive hybrids. For reciprocal cross groups MH and HM, the time required for the embryos to develop into D-shaped larva was less than that required for embryos in the inbred groups MM and HH (MH 18 h, HM 19 h, MM 21 h, and HH 22 h). The average fertilization rate and average hatching rate of the MH and HM groups were lower than those of the MM and HH groups. Under different temperature, salinity, and sperm concentration, the fertilization rate and hatching rate of reciprocal cross groups MH and HM were lower than those of the MM and HH groups. A comparison of the growth of planktonic larvae among four experimental groups from day 2 to day 11 revealed that the shell length and height of the MH and HM groups were significantly higher than those of the MM and HH groups, with both showing obvious heterosis (<0.01). Experiments designed to predict the larvae of the orthogonal and reciprocal groups on the basis of the inbred group in shell length and height revealed that the growth tendency of hybrid scallop can be predicted using the BP neural network model method, and the error rate of the predicted values was less than 4%.