The present study was conducted to investigate the effects of exercise training on the growth, serum innate immunity, and hepatic antioxidant capacity of orange-spotted grouper (). The fish were exercised at an intensity of 0, 0.5, 1, and 2 body lengths per second (bl/s) for 8 weeks. Specific growth, weight gain, and survival increased significantly in the 1 bl/s group (<0.05). The plasma concentrations of total protein, globulin protein, complement 3, lysozyme, alkaline-phosphatase, and acid phosphatase increased as exercise intensity increased up to 1 bl/s and then decreased at the higher intensity of 2 bl/s (<0.05). The plasma contents of glutamic-pyruvic transaminase and glutamic-oxaloacetic transaminase decreased as the exercise intensity increased up to 1 bl/s, and then increased at the higher intensity of 2 bl/s (<0.05). The albumin and complement 4 contents of plasma did not significantly differ among treatments. Hepatic total antioxidant capacity, catalase, and superoxide dismutase activity increased with exercise intensity up to 1 bl/s and then decreased at 2 bl/s (<0.05). The exercise treatments significantly affected the mRNA e xpression of HSPs70, and that of the 1 bl/s group was the highest. The results indicated that an exercise intensity of 1 bl/s effectively enhanced the growth, serum innate immunity, hepatic antioxidant capacity, and HSPs70 mRNA expression of .