Halophilic archaea inhabit hypersaline environments and are an important component of microbial communities. High salt concentration enable archaea cells accumulating bioactive compounds with unique molecular structure and biochemical functions. Therefore, archaea are also important resources for commercial application. As a non-selective filter feeder, plays an important role in the food chains of hypersaline environments, even though the high salinity of such environments limits the complexity of the food web. It is well known that populations are supported by rich phytoplankton communities. Recently, the important role of microbiota in the life cycle of and in hypersaline food chain has drawn much interest. The present study focused on archaea, which are important but often neglected microorganisms that comprise the third domain of life. Their cells contain ether-linked membrane lipids, instead of the ester-lipids found in bacterial and eukaryotic cells. Archaea are considered unsuitable as a food resource for aquatic animals, since the ether-linked lipids are difficult to digest and do not provide the essential fatty acids needed to support animal growth and survival.Haloferax sp. KN-4, and sp. IT-5) were isolated from a crystallization pond of a solar saltworks. The gnotobiotic can survive on a sole diet of halophilic archaea and to investigate the effect of halophilic archaea on at different salinities (30, 100, and 150, respectively). The archaea cells were cultured at 100 and 150, with modified CM medium. All three halophilic archaea strains grew faster at 150, and under the condition of salinity 100, the growth of Halorubrum sp. IT-5. that were fed the three archaeal strains exhibited higher survival rates and body lengths when cultured at salinity 30 than when cultured at salinity 100 or salinity 150. The greatest survival rate was observed when the sp. IT-5 at salinity 100, whereas the greatest body length was observed when the sp. HG-1 at salinity 100. When challenged with , the survival rate of all groups decreased, but the greatest survival rate and body length were observed when the sp. KN-4. At salinity 100 and 150, all the V. Anguillarum-challenged generally exhibited greater survival rates and body lengths than the unchallenged groups, thereby indicating that the virulence of decreased at high salinity and the cells could be ingested as food by -archaea experimental system, the present study provides evidence that can survive and grow on a sole diet of halophilic archaea over a wide range of salinities (30-150). In addition, halophilic archaea can improve , a pathogen that frequently occurs in marine aquaculture systems. These results provide a basis for investigating the role of archaea in the food chains of hypersaline environments.