Animals that inhabit intertidal areas long-term can sense the local tidal rhythm, forming a tidal memory. However, to date, no studies have investigated the mechanism of tidal rhythm sensing in in the laboratory using low-frequency tide sounds. The cDNA sequence of the gene was cloned by RACE-PCR, after which bioinformatics analysis and qRT-PCR experiments were performed. The results showed that the full-length cDNA of the gene was 2321 bp (366 bp 5' non-coding region (UTR), 1337 bp 3' non-coding region (UTR), and 618 bp open reading frame (ORF), which encoded a total 206 amino acids. The gene that encodes polypeptide chains was predicted with an atomic number of 3165, a molecular weight of approximately 23029.64 kD, a theoretical isoelectric point of 4.64, a molecular formula of C₁₀₁₈H₁₅₄₄N₂₇₄O₃₂₀S₉, and an N-terminal signal peptide composed of 29 amino acids. The phylogenetic tree was constructed via amino acid sequence alignment. The results suggest that the like gene of , which is consistent with traditional morphological classification. The distribution of genes in different tissues was detected using qRT-PCR. The results indicated that , but the expression of ganglion was significantly higher than dorsal skin, pleopod, intestines, liver, mouthparts, and albumen gland (<0.05). We speculated that it may be involved in the plasticity regulation of the ganglion system. The quantitative fluorescence results indicated that the genes were highly expressed, underlying the stimulation of low frequency sound waves at 25 Hz and 50 Hz for 12.4 h, respectively, for which it was presumed that could sense the 25-50 Hz sound frequency. This may be related to the tidal memory formed by the long-term immersion in the 12.4 h half-day tidal cycle rhythm in the intertidal zone. This study will lay the foundation for further understanding of the molecular mechanisms of sensing tidal rhythm, and provide a basis for exploring the environmental adaptation mechanism of marine animals from ocean to land evolution.