With the current situation of resource depletion and environmental changes, artificial reefs may be used to promote the fish trapping and breeding to proliferate and conserve fishery resources and restore the ecosystems. The main idea of artificial reef construction was to stimulate the production and transmission of nutrients, sediment size, and primary productivity through the unique flow field generated around the reef, and to proliferate plankton, pelagic swimming organisms, and benthic resources in the form of food supply and habitat transformation. Therefore, the flow field effect of artificial reefs was based on ecological-biological interactions. The strength of the flow field effect is affected by the scale of artificial reef unit. The measurement of the artificial reef construction mode was one of the most important factors for planning the scale of artificial reef construction. The flow field volume was an important indicator to characterize the flow field effect. Based on the numerical experimental method, this paper analyzed the variation of the flow field volume of Mi-zi artificial reefs in 28 kinds of artificial reef scale units in four laying modes, and established the multivariate nonlinear model for the flow field volume of upwelling and back eddy and artificial reef construction model indicators. The results showed that in the primary indicators of artificial reef construction, the throwing amount () and target velocity ratio () and upwelling volume were linear, cubic, and power function, respectively. Combining the relative length (R) of the secondary index to establish the upwelling volume regression model was -0.055_u^-1.833+0.227_b=r)-51.779d× were 0.957 and 0.938, and the relative errors were 18.61% and 10.09%, respectively. The flow field volume regression model can be used to plan the construction of artificial reefs that guide the uniform laying mode, and gradually realize the artificial reef construction strategy of "reducing mass and improving efficiency".