An experiment was conducted to determine effects of refeeding after starvation on lipid peroxidation and antioxidant defenses of foot muscle and hepatopancreas of . The results indicated that the malondialdehyde content of the snails were significantly higher than that of the controls after food was deprived for 25 d and 40 d respectively. The activities of the antioxidant enzymes of superoxide dismutase （（ were significantly higher than those in control in two tissues when food deprivation were not more than 25 dbut the results were reverse after the snails were starved for 40 d. The activities of glutathione-S-transferase reduced after increased firstly during starvation periodwhich were significantly lower than those in controls in muscle and hepatopancreas when starved time was up to 25 d and 40 d respectively. Both of the activities of glutathione reductase and the contents of GSH decreased graduallywith the starved time prolonged. After the snails were refed for 30 dalmost all the levels of the biomarkers of the snails returned to control values except MDA contents in hepatopancreas and GR activities in the 40 d starved group. In conclusionprolonged starvation led to a pro-oxidant situation and oxidative stress despite activation of antioxidant defense mechanismand the fasting time for the snails was best not more than 25 d during culture period when necessary. The activities of SODCAT and GPx could be used as good indexes to indicate the status of snails when food is deprived.