Studying the ecology of fish parasite population is useful to understand the distribution characteristics of all individuals of the same population in a certain time and space, in addition to the growth and decline of the parasite population. In addition, it is important to study the relationship among parasite, host, and environment. There are many rivers and lakes in Tibet with a unique fish composition. However, little attention has been paid to the parasites of the indigenous fish in Tibet, and the research on the population ecology is very limited. Only the native fish in Lhasa River and Lake Chugutso and Glyptosternum maculatum in the Yarlung Zangbo River have been reported. Yamdrok Lake is located in the south of Tibet, and it is the largest lakes in the south of the Yarlung Zangbo River and the north of the Himalayas. Gymnocypris waddellii is the only Schizothorax fish in this lake with no known studies on its parasites. In this study, we evaluated the status of intestinal helminths of G. waddellii in Yamdrok Lake to further understand the fauna composition and characteristics of parasites of native fishes in Tibet. Our study may contribute to further research about fish, parasites, plateau uplift, and special geographical environments. We dissected 180 G. waddellii individuals in July 2020, identified and counted the parasitic helminths, and analyzed their spatial dynamics and distribution patterns. We found five intestinal helminths spe-cies: Parabreviscolex niepini, Contracaecum eudyptulae, Streptocara sp., Neoechinorhynchus sp., and Al-locreadium sp. The prevalence of Neoechinorhynchus sp. was the highest; the infection intensity and mean abun-dance of P. niepini was the highest; and the prevalence, infection intensity, and mean abundance of Streptocara sp. were the lowest. Moreover, t-test of independent samples showed that there was no significant difference in the mean abundance of male and female populations infected with intestinal helminths. The results of correlation analysis showed that there was no significant correlation between the total length of the host and the number of intestinal helminths. Distribution patterns of the five populations were analyzed by variance mean ratio, and the results showed that they were aggregated. The host frequencies in each population were fitted with a negative bi-nomial distribution, and the significance of the results was analyzed using x² -test. Although the populations of P. niepini and Streptocara sp. were aggregated, they did not conform to the negative binomial distribution. Among the five populations, the uninfected hosts had the highest frequency. In case of infection, the host frequency of P. niepini infected with 1–5 was the highest, C. eudyptulae and Allocreadium sp. infected with 1 was the highest, Neoechinorhynchus sp. infected with 1–2 was the highest, and the host frequency of Streptocara sp. was lower and similar when the number of infections was 1–6.