Curcumin is a natural yellow pigment derived from turmeric and tulip rhizome, has been widely used as feed additives to improve the health of cultured animals due to its highly biologically active and functions of anti-inflammatory, antioxidant, and blood lipid-lowering. However, the application of curcumin is rarely studied in sturgeon, which is intensively cultured because of the high value of nutritional and economic. Therefore, to investigate the effect of curcumin on the growth and health of sturgeon, a 6–week feeding trial was conducted using hybrid sturgeon (Acipenser baeri♂×Acipenser schrenckii♀). A total of 300 juvenile hybrid sturgeon with an initial weight of (16.24±0.11) g were assigned to diets containing 0 g/kg, 0.025 g/kg, 0.05 g/kg, 0.1 g/kg and 0.2 g/kg curcumin in triplicated. The results showed that the addition of curcumin in the feed had no significant effect on the growth performance and body composition of juvenile hybrid sturgeon. Curcumin addition significantly decreased serum TG content in the group of 0.2 g/kg curcumin in diets (P＜0.05), ALT and AST activities in hybrid sturgeon liver were reduced with the curcumin level increasing, which appeared significant difference with control at the curcumin level at 0.2 g/kg and 0.05 g/kg, respectively (P＜0.05). Curcumin significantly improved the activity of protease in duodenum with curcumin level increasing at first, which showed the highest activity at 0.05 g/kg of curcumin supplementation respectively (P＜0.05), and then decreased with curcumin further increasing. Curcumin addition improved the activity of α-AMY significantly at 0.1 g/kg of curcumin supplementation respectively (P＜0.05), and then decreased. The results of antioxidants showed that serum MDA content decreased significantly in the group of 0.025 g/kg curcumin (P＜0.05), in which group serum CAT activity increased significantly (P＜0.05). While a significant increase of CAT activity in the liver appeared in the curcumin addition level at 0.05 g/kg (P＜0.05). There was no significant difference among the treatments even though decreased MDA content and increased SOD activity appeared in the liver. MDA content, SOD and CAT activities in duodenum showed a similar change pattern with that in serum, however, no significant effect was observed by curcumin addition. Histopathology results of duodenum indicated that curcumin addition in feed could improve the structure of intestine, which showed clear and fewer adherent villi structures. The present study indicated that the appropriate curcumin supplementation in feed was beneficial to the health of hybrid sturgeon, which could improve the antioxidant capacity of the fish, promote the health of liver and intestine, in the meantime, decrease the lipid. In conclusion, according to the current study, the addition of 0.025–0.05 g/kg of curcumin was suggested in hybrid sturgeon diets. This study could provide scientific basis for curcumin supplementation in sturgeon feed, ultimately help the health development of sturgeon aquaculture.