This study is aimed to discuss the effects of waves combined with currents on forces and motion deformation of deep-water net cages, and provides a strong reference to risk assessment for net-cage aquaculture with severe marine conditions. The set value of wave and current elements were as follows: wave heights 4-0.9 m/s. With a numerical model previously validated by physical model tests, the mooring line forces, the wave-current forces, the volume reduction rate and the floating-collar pitches of the deep-water net cage were calculated. The simulated results indicated that the mooring line force, the wave-current force and the volume reduction rate were all in direct proportion to wave height as well as current velocity, but less related to wave period. Furthermore, the wave-current force on the cage was approximately equal to the sum of force on each mooring line on wave-side. The volume reduction rate reached 56% for the cage caused by the conditions of wave height of 46 m and current velocity of 0.75m/s, which showed serious cage deformation. Therefore, we concluded that farming sites should not be placed in sea areas where current speed exceeded 0.75 m/s. The calculated results also showed that the influence of wave period on volume reduction rate was slight, while significant on the floating-collar pitch. The floating-collar pitch would decrease as wave period increasing at constant wave height and current velocity.