and Li⁺ on were tested in laboratory. The results of acute toxic test showed that had high tolerance to the 5 metals, and the order of the toxicity of these metals to > Ni²⁺> Li⁺. The values of 24 h EC₅₀ of the 5 metals on were 12.75 mg/L, 18.32 mg/L, 83.26 mg/L, 196.97 mg/L and 386.34 mg/L, respectively, and were 3.27 mg/L, 4.96 mg/L, 27.49 mg/L, 66.09 mg/L and 325.42 mg/L for 48 h, respectively. The results of joint toxicity showed that the effects of equivalent toxicity of Cu+Zn, Co+Ni, Co+Li, Ni+Li, Co+Ni+Li, Cu+Zn+Co and Cu+Zn+Co+Ni+Li on were antagonistic, but the effects of equivalent toxicity of Cu+Zn+Ni, Cu+Zn+Li and Cu+Zn+Co+Ni were antagonistic at 24 h, while synergetic at 48 h. From the results we can speculate that has high tolerance to metal ions and combination of metal ions. Particularly,+. These two aspects, rapid growth and fast reproduction under high concentrations of metals in saline lakes in Tibet, especially under high concentration of Li⁺.