+高级检索
首页 > 过刊浏览>2012年第19卷第1期 >154-160
PDF HTML阅读 XML下载 导出引用 引用提醒
黄芩苷与甘草酸对恩诺沙星在异育银鲫体内代谢的影响
作者:
作者单位:

1. 中国水产科学研究院 东海水产研究所 农业部海洋与河口渔业资源及生态重点开放实验室, 上海 200090;2. 上海海洋大学 国家水生动植物病原库, 上海 201306

作者简介:

房文红, 研究员, 从事水产动物药理学研究.Tel:021-65699301；E-mail: whfang06@yahoo.com.cn

基金项目:

农业部公益性行业科研专项(201203085); 中央级公益性科研院所基本科研业务费专项资金(中国水产科学研究院东海水产研究所)(2007M06).


Effect of baicalin and glycyrrhizin on enrofloxacin in vivo in crucian carp (Carassius auratus gibelio)
Author:
  • FANG Wenhong1

    FANG Wenhong1

    1. East China Sea Fisheries Research Institute, Chinese Academy of Fishery sciences; Key Laboratory of Marine and Estuarine Fisheries Resources and Ecology, Ministry of Agriculture, Shanghai 200090 China;2. National Pathogen Collection Center for Aquatic
    在期刊界中查找
    在百度中查找
    在本站中查找
  • ZHOU Chang1.2

    ZHOU Chang1.2

    1. East China Sea Fisheries Research Institute, Chinese Academy of Fishery sciences; Key Laboratory of Marine and Estuarine Fisheries Resources and Ecology, Ministry of Agriculture, Shanghai 200090 China;2. National Pathogen Collection Center for Aquatic
    在期刊界中查找
    在百度中查找
    在本站中查找
  • SUN Beibei1

    SUN Beibei1

    1. East China Sea Fisheries Research Institute, Chinese Academy of Fishery sciences; Key Laboratory of Marine and Estuarine Fisheries Resources and Ecology, Ministry of Agriculture, Shanghai 200090 China;2. National Pathogen Collection Center for Aquatic
    在期刊界中查找
    在百度中查找
    在本站中查找
  • LI Guolie1

    LI Guolie1

    1. East China Sea Fisheries Research Institute, Chinese Academy of Fishery sciences; Key Laboratory of Marine and Estuarine Fisheries Resources and Ecology, Ministry of Agriculture, Shanghai 200090 China;2. National Pathogen Collection Center for Aquatic
    在期刊界中查找
    在百度中查找
    在本站中查找
  • YANG Xianle2

    YANG Xianle2

    1. East China Sea Fisheries Research Institute, Chinese Academy of Fishery sciences; Key Laboratory of Marine and Estuarine Fisheries Resources and Ecology, Ministry of Agriculture, Shanghai 200090 China;2. National Pathogen Collection Center for Aquatic
    在期刊界中查找
    在百度中查找
    在本站中查找
  • LI Xincang1

    LI Xincang1

    1. East China Sea Fisheries Research Institute, Chinese Academy of Fishery sciences; Key Laboratory of Marine and Estuarine Fisheries Resources and Ecology, Ministry of Agriculture, Shanghai 200090 China;2. National Pathogen Collection Center for Aquatic
    在期刊界中查找
    在百度中查找
    在本站中查找
  • HU Linlin1

    HU Linlin1

    1. East China Sea Fisheries Research Institute, Chinese Academy of Fishery sciences; Key Laboratory of Marine and Estuarine Fisheries Resources and Ecology, Ministry of Agriculture, Shanghai 200090 China;2. National Pathogen Collection Center for Aquatic
    在期刊界中查找
    在百度中查找
    在本站中查找

  • 1. East China Sea Fisheries Research Institute, Chinese Academy of Fishery sciences; Key Laboratory of Marine and Estuarine Fisheries Resources and Ecology, Ministry of Agriculture, Shanghai 200090 China;2. National Pathogen Collection Center for Aquatic
    在期刊界中查找
    在百度中查找
    在本站中查找
Affiliation:

1. East China Sea Fisheries Research Institute, Chinese Academy of Fishery sciences; Key Laboratory of Marine and Estuarine Fisheries Resources and Ecology, Ministry of Agriculture, Shanghai 200090 China;2. National Pathogen Collection Center for Aquatic

  • 摘要
    • | |
  • 访问统计
    • |
  • 参考文献 [1]
    • |
  • 相似文献 [20]
    • |
  • 引证文献
    • | |
  • 文章评论
    摘要:

    (10 mg/kg), <0.05)GZ1.76%, N--O-EROD, CYP1A和

    Abstract:

    Cytochrome P450s (CYPs) widely distribute in the liver of aquatic organisms and play a key role in drug metabolism. CYPs catalyze the N-deethylation of (CIP). However, there is limited information regarding the action of CYPs in fish. We evaluated the of baicalin (100 mg/kg). We measured the enzymatic activity of cytochrome P450 1A (CYP1A) and 3A (CYP3A) in liver microsomes. In addition, we documented the pharmacokinetics of decreased significantly over time and both CL inceased after oral administrated of elimination was accelerated. The was 1.48% and 2.22% for the BL and GZ groups, respectively (control: 0.95%). The AUCwas 2.16% and 1.76% for the BL and GZ groups, respectively (control: 1.7%). Thus, BL and GZ contributed to induce N-deethylation of . Pretreatment with significant erythromycin-N-demethylation (ERND) activity, the specific probes for CYP1A and CYP3A, BL and GZ accelerated the elimination of metabolite was related to the induction of CYP1A and CYP3A enzymatic activity.

    参考文献

           赵晓梅. 常见的中西药相互作用分析中华现代中西医杂志

           刘彦卿洪燕君曾苏代谢性药物药物相互作用的研究进展浙江大学学报医学版, 2009, 28(2): 215–224.

           艾常虹李桦董德利基于细胞色素酶诱导的药物相互作用及评价国际药学研究杂志

           Kubota Y, Kobayashi K, Tanaka N, et al. Pretretment with Ginkgo biloba extract weakens the hypnosis action of Phenobarbital and its plasma concentration in rats [J]. Pharmacology, 2004, 56(3): 401–405.

           Harkey M R, Henderson G L, Gershwin M E, et al. Variability in commercial ginseng products: An analysis of 25 preparations [J]. Am J Clin Nutr, 2001, 73: 1101–1106.

           Isbrucker R A, Burdock G A. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin [J]. RegulToxicol Pharmacol, 2006, 46: 167–192.

           Chang H H, Yi P L, Cheng C H, et al. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation [J]. J Ethnopharmacol, 2011, 135(2): 359–368.

           Velpandian T, Jasuja R, Bhardwaj R K, et al. Piperine in food: interference in the pharmacokinetics of phenytoin [J]. Eur J Drug M etab Pharmacokinet, 2001, 26(4): 241–247．

           刘建群李青张锐等法研究甘草对雷公藤甲素药代动力学及组织分布与排泄的影响药物分析杂志, 2010, 30(9): 1664–1671.

        杨先乐水产养殖用药处方大全化学工业出版社

        Novi S, Pretti C, Cognetti A M, et al. Biotransformation enzymes and their induction by β-naphtoflavone in adult sea bass (Dicentrarchus labrax) [J]. Aquat Toxicol, 1998, 41: 63–81.

        Lange U, Goksøyr A, Siebers D, et al. Cytochrome P450 1A-dependent enzyme activities in the liver of dab (Limanda limanda): kinetics, seasonal changes and detection limits [J]. Comp Biochem Physiol, 1999, 123B: 361–371.

        Tu Y Y, Yang C S. High-affinity nitrosamine dealkylase system in rat liver microsomes and its induction by fasting [J]. Cancer Res, 1983, 43: 623–629.

        何益军, 石苏英, 金科涛, 等. 甘草与大戟甘遂芫花配伍对大鼠肝脏细胞色素P4501A2酶活性的影响[J]. 中国药物与临床, 2007, 7(4): 278–280.

        涂江华. 甘草酸对CYP450酶的影响及其机制研究[D]. 长沙: 中南大学, 2010.

        Li Y, Wang Q, Yao X M, et al. Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor-and pregnane X receptor-mediated pathways [J]. Eur J Pharmacol, 2010, 640: 46–54.

        韩华, 李健, 李吉涛, 等. 黄芩苷对牙鲆肝 CYP1A 酶活性及基因表达的影响[J]. 中国水产科学, 2010, 17(5): 1121–1127.

        艾常虹, 孙汉雄, 李桦, 等. 中药有效成分对细胞色素P450酶的抑制活性评价[J].中国药理学通报, 2011, 27(4): 519–523.

        Vaccaro E, Giorgi M, Longo V, et al. Inhibition of cytoc- hrome P450 enzymes by enrofloxacin in the sea bass (Dicentrarchus labrax) [J]. Aquat Toxicol, 2003, 62:27–33.

        Yoo H H, Kim N S, Lee J, et al. Characterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone [J]. Xenobiotica, 2009, 39: 1–10.

        李馨, 吴笑春, 辛华雯, 等. 盐酸黄连素对环孢素增效作用的药物动力学研究[J]. 华南国防医学杂志, 2002, 16(1): 12–15.

        刘晓磊, 唐靖, 宋娟, 等. 川芎嗪对大鼠灌服环孢素A药代动力学的影响[J]. 药学学报, 2006, 41( 9): 882–887.

        Schinkel A H, Jonker J W. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview [J]. Adv Drug Deliv Rev, 2003,55(1): 3–29.

        Bauer S, Stormer E, Johne A, et al. Alterations in cyclosporin A pharmacokinetics and metabolism during treatment with St John’s wort in renal transplant patients[J]. Br J Clin Pharmacol, 2003, 55:203–211.

        范岚. 黄芩苷对CYP450代谢酶和药物转运体影响的研究[D]. 长沙: 中南大学, 2008.

        颜苗. 甘草酸18位差向异构体及其水解产物对P-糖蛋白影响的研究[D].. 长沙:中南大学, 2010.

        Seelig A, Landwojtowicz E. Structure–activity relationship of P-glycoprotein substrates and modifiers [J]. Eur J Pharmacol Sci, 2000, 12:31–40.

        Schrickx J A, Gremmels J F. Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters [J]. Br J Pharmacol, 2007, 150(4):463–469.

        Seelig A, Landwojtowicz E. Structure–activity relationship of P-glycoprotein substrates and modifiers [J]. Eur J Pharmaceutical Sci, 2000, 12:31–40.. [M]. : , 2008.

    网友评论
    网友评论
    分享到微博
    发 布
引用本文

房文红,周常,孙贝贝,李国烈,杨先乐,李新苍,胡琳琳.黄芩苷与甘草酸对恩诺沙星在异育银鲫体内代谢的影响[J].中国水产科学,2012,19(1):154-160
FANG Wenhong, ZHOU Chang.,SUN Beibei, LI Guolie, YANG Xianle, LI Xincang, HU Linlin. Effect of baicalin and glycyrrhizin on enrofloxacin in vivo in crucian carp (Carassius auratus gibelio)[J]. Journal of Fishery Sciences of China,2012,19(1):154-160

复制
分享
文章指标
  • 点击次数:1395
  • 下载次数: 573
  • HTML阅读次数: 0
  • 引用次数: 0
历史
  • 在线发布日期: 2012-02-02
文章二维码
您是第1043561 位访问者
主管单位：中华人民共和国农业农村部
主办单位：中国水产科学研究院  中国水产学会  科学出版社
地址：北京市永定路南青塔村150号
传真：010-68673931 电话：010-68673921,010-68673931
中国水产科学 ® 2025 版权所有