The aim of this experiment was to evaluate the effects of replacing fish meal with maggot meal on the nutritional composition, physiochemical indexes, amino and fatty acid composition of yellow catfish () muscle. Nine hundred and sixty fish with an initial body weight of ~2 g were randomly assigned to six groups and fed one of six isonitrogenous (39.5%) and isonergetic (16.8 MJ/kg) diets replacing 0% (G0), 20% (G20), 40% (G40), 60% (G60), 80% (G80) and 100% (G100) fish meal with maggot meal on a protein basis. After 60 days of the feed trial, there was no significant difference in muscle moisture, crude protein or crude lipid content among all treatments (0.05), but ash content of G60~G100 was significantly higher than that of G0 (0.05). No significant difference was found in pH, drip lose (DL), cooking lose (CL) or superoxide dismutase (SOD) activities among all groups (0.05). Compared with G0, there was no significant difference in collagen content with maggot meal treatments (0.05), but muscle malondialdehyde (MDA) content of G40 and G60 decreased significantly (0.05). Arginine, histidine, phenylalanine and total essential amino acid content in G80 were significantly higher than in G0 (0.05). No significant difference was observed in total amino acid, glutamic, glycine, alanine, aspartate or total flavor EPA and DHA, polyunsaturated fatty acids (PUFA), n-3 PUFA content and n-3/n-6 ratio decreased with increasing maggot meal content, with significant diminution in G60~G100 compared with G0 ( and monounsaturated fatty acid (MUFA) content in G60 and G100 increased significantly (0.05). In conclusion, maggot meal had no significant effect on the nutritional composition, physiochemical indexes, amino acid or fatty acid composition in the muscle of , with the exception of MDA content, which significantly decreased when maggot meal replacement was less than 40%.