鱼类高度不饱和脂肪酸合成的影响因素及其机理
作者:
作者单位:

汕头大学 海洋生物研究所, 广东省海洋生物技术重点实验室, 汕头 515063

作者简介:

谢帝芝(1986), 男, 博士研究生, 专业方向为鱼类分子营养. E-mail: 11dzxie@stu.edu.cn

中图分类号:

S963

基金项目:

国家自然科学基金重大国际合作研究项目(31110103913); 国家自然科学基金面上项目(30972266); 国家自然科学基金青年基金项目(31202012; 31202011); 教育部高等学校博士学科点专项科研基金(20104402110002); 广东省自然科学基金面上项目(S2011010005219); 广东省高等学校高层次人才项目(2010-79).


Influencing factors and mechanisms on HUFA biosynthesis in teleosts
Author:
Affiliation:

Guangdong Provincial Key Laboratory of Marine Biotechnology in Shantou University, Shantou 515063, China

  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献 [1]
  • |
  • 相似文献 [20]
  • |
  • 引证文献
  • | |
  • 文章评论
    参考文献

           Xiao Y F, Ke Q, Wang S Y, et al. Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels [J]. Proc Natl Acad Sci USA, 2001, 98: 3603-3611.

           Sargent J R, Tocher D R, Bell J G. The Lipids. Fish Nutrition [M]. 3rd ed. San Diego: Academic Press,

           Cook H W, McMaster R C R. Fatty acid desaturation and chain elongation in eukaryotes[M]// Vance JE, Vance D E.Biochemistry of Lipids, Lipoproteins and Membranes. 4th ed. Amsterdam: Elsevier, 2004.

           Li Y Y, Oscar M, Liang Z, et al. Vertebrate fatty acyl desatu­rase with D4 activity [J]. PNAS, 2010, 28: 16840-

           Morais S, Castanheira F, Martinez-Rubio L, et al. Long chain polyunsaturated fatty acid synthesis in a marine vertebrate: Ontogenetic and nutritional regulation of a fatty acyl desa­turase with Δ4 activity [J]. Biochimica et Biophysica Acta, 2012, 1821: 660-671.

           Tocher D R, Dickson C A, et al. Effects of diets containing vegetable oil on expression of genes involved in polyunsaturated fatty acid biosynthesis in liver of Atlantic salmon (Salmo salar) [J]. Aquaculture, 2004, 236: 467– 483.

           Kennedy S R, Leaver M J, Tocher D R, et al. Influence of dietary oil content and conjugated linoleic acid (CLA) on lipid metabolism enzyme activities and gene expression in tissues of Atlantic salmon (Salmo salar) [J]. Lipids, 2006, 5: 423–436.

           Seiliez I, Panserat S, Corraze G, et al. Cloning and nutritional regulation of a Δ6-desaturase- like enzyme in the marine teleost gilthead seabream (Sparus aurata) [J]. Comp Bio­chem Physiol, 2003, 135B: 449–460.

           Tocher D R, Bell J G, Dick J R, et al. Effects of vegetable oil diets on Atlantic salmon hepatocyte desaturase activities and liver fatty acid compositions[J]. Lipids, 2003, 38 (7): 723– 732.

        Park W J, Kothapalli K S, et al. An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8- desaturates 20:2n-6 and 20:3n-3 [J]. J Lipid Res, 2009, 50 (6): 195-202.

        Monroig Ó, Li Y Y, Tocher D R. Delta-8 desaturation activity varies among fatty acyl desaturases of teleost fish: high activity in delta-6 desaturases of marine species[J]. Comp Biochem Physiol, 2011, 159 (4): 206-

        Izquierdo M S, Robaina L, Juárez-Carrillo E, et al. Regula­tion of growth, fatty acid composition and delta-6 desaturase expression by dietary lipids in gilthead seabream larvae (Sparus aurata) [J]. Fish Physiol Biochem, 2008,

        Ontogenic effects of early feeding of sea bass () larvae with a range of dietary n−3 HUFA levels on the function of polyunsaturated fatty acid desaturation pathways

        Leaver M J, Villeneuve L A N, Tocher D R, et al. Functional genomics reveals increases in cholesterol biosynthetic genes and highly unsaturated fatty acid biosynthesis after dietary substitution of fish oil with vegetable oils in Atlantic salmon (Salmo salar) [J]. BMC Genom, 2008, 9: 299.

        Tocher D R, Zheng X, Schlechtriem C, et al. Highly unsaturated fatty acid synthesis in marine fish: cloning, functional characterization, and nutritional regulation of fatty acyl Δ6 desaturase of Atlantic cod (Gadus morhua.) [J]. Lipids, 2006,

        Ruyter B, Grisdale-Helland B, Rosenlund G, et al. Influence of temperature and high dietary linoleic acid content on esterificauion, elongation, and desaturation of PUFA in Atlantic Salmon hepatocytes [J]. Lipids, 2003, 38: 833-

        Bell J , McEvoy J, Tocher D R, et al. Replacement of fish oil with rapeseed oil diets of Atlantic salmon (Salmo salar) affects tissue lipid compositions and hepatocyte fatty acid metabolism [J]. J Nutr, 2001, 131: 1535–1543.

        Leonard A E, Kelder B, Bobik E G, et al. Identification and expression of mammalian long-chain PUFA elongation enzymes [J]. Lipids, 2002, 37: 733–740.

        Zhang K, Kniazeva M, Han M, et al. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy [J]. Nat Gen, 2001, 27: 89–93.

        Jakobsson A, Westerberg R, Jacobsson A. Fatty acid elon­gases in mammals: their regulation and roles in metabolism [J]. Progr Lip Res, 2006, 45: 237–249.

        Morais S, Monroig O, Tocher D R, et al. Highly unsaturated fatty acid synthesis in Atlantic Salmon characterization of ELOVL5- and ELOVL2-like elongases [J]. Mar Biotechnol, 2009(11): 627-

        Horton J D, Shah N A, Warrington J A, et al. Combined analysis of oligo-nucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes [J]. Proc Natl Acad Sci U S A, 2003, 100: 12027–12032.

        Turchini G M, Francis D S. Fatty acid metabolism (desaturation, elongation and b-oxidation) in rainbow trout fed fish oil- or linseed oil-based diets [J]. Brit J Nutr, 2009, 102: 69–81.

        Thomassen M S, Rein D, Berge G M. High dietary EPA does not inhibit Δ5 and Δ6 desaturases in Atlantic salmon (Salmo salar) fed rapeseed oil diets [J]. Aquaculture, 2012, 360--

        Sargent J R, Henderson R J, Tocher D R, et al. The lipids // Halver J E. Fish Nutrition: 2nd ed. New York: Academic Press, 1989.

        Bell M V, Dick J R. Distribution of 22:6n-3 newly synthesized from 18:3n-3 into glycerolipid classes from tissues of rainbow trout () [J]. Lipids, 2005, 40: 703-

        Stubhaug I, Tocher D R, Bell J G, et al. Fatty acid metabolism in Atlantic salmon (Salmo salar L.) hepatocytes and influence of dietary vegetable oil [J]. Biochim Biophys Acta, 2005, 1734: -

        Leyton J, Drury P J, Crawford M A. Differential oxidation of saturated fatty acids in vivo in the rat [J]. -

        Tocher D R, Fonseca-Madrigal J, Bell J G, et al. Effects of diet containing linseed oil on fatty acid desaturation and oxidation in hepatocytes and intestinal enterocytes in Atlantic salmon (Salmo salar) [J]. Fish Physiol Biochem, 2002, 26: 157-

        Li Y, Hu C, Zheng Y, et al. The effects of dietary fatty acids on liver fatty acid composition and delta-6 desaturase expres­sion differ with ambient salinities in Siganus canaliculatus [J]. Comp Biochem Physiol, 2008, 151: 183-

        Bell J G, Henderson R J, Tocher D R, et al. Substituting fish oil with crude palm oil in the diet of Atlantic salmon (Salmo salar) affects tissue fatty acid composition and hepatic fatty acid metabolism [J]. J Nutr, 2002, 132: 222-

        Izquierdo M S, Robaina L, Juárez-Carrillo E, et al. Regulation of growth, fatty acid composition and delta-6 desaturase ex­pres­sion by dietary lipids in gilthead seabream larvae (Sparus aurata) [J]. Fish Physiol Biochem, 2008, 34: 117-

        Zheng X, Torstensen B E, Tocher D R, et al. Environmental and dietary influences on highly unsaturated fatty acid biosynthesis and expression of fatty acyl desaturase and elongase genes in liver of Atlantic salmon (Salmo salar) [J]. Biochim Biophys Acta, 2005, 1734: 13-

        Ruyter B, Røsjø,C, Måsøval K, et al. fluence of dietary n−3 fatty acids on the desaturation and elongation of [1-14C] 18:2n−6 and [1-14C] 18:3n−3 in Atlantic salmon hepatocytes [J]. Fish Physiol Biochem, 2000, 23: 151-

        Kamal-Eldin A, Appelqvist L-A. The chemistry and antioxidant properties of tocopherols and tocotrienols [J]. Lipids, 1996, 31: 671-

        Sies H. Oxidative Stress: Oxidants and Antioxidants[M]. New York: Academic Press, 1994.

        Stephan G, Guillaume J, Lamour F. Lipid peroxidation in turbot (Scophthalmus maximus) tissue: effect of dietary vitamin E and dietary n-6 or n-3 polyunsaturated fatty acids [J]. Aquaculture, 1995, 130: 251-

        Witting L A, Horwitt M K. The effect of antioxidant deficiency on tissue lipid composition in the rat. I gastrocemius and quadriceps muscle [J]. Lipids, 1967, 2: 89-

        Buttriss J L, Diplock A T. The a-tocopherol and phospholipid fatty acid content of rat liver subcellular membranes in vitamin E and selenium deficiency [J]. Biochim Biophys Acta, 1988, 963: 61–69.

        Baker R T M, Davies S J. Increased production of docosahexaenoic acid (22:6n-3, DHA) in catfish nutritionally stressed by the feeding of oxidized oils and the modulatory effect of dietary a-tocopheryl acetate [J]. J Fish Biol, 1996, 49: 748-

        , , .Depletion of a-Toco­pherol and astaxanthin in Atlantic Salmon (Salmo salar) affects autoxidative defense and fatty acid metabolism [J]. J Nutr, 2000, 130: 1800-

        Infante J P. Vitamin E and selenium participation in fatty acid desaturation: a proposal for an enzymatic function of these nutrients [J]. Mol Cell Biochem, 1986, 69: 93-

        Toren P, Eldar S, Sela B A, et al. Zinc deficiency in attention- deficit hyperactivity disorder [J]. Biol Psychiatry, 1996, 40(12): 1308-

        Eugene A L, Disilvestro R A. Zinc in attention-deficit/ hyperactivity disorder [J]. J Child Adolesc Psychpharmac, 2005, 15: 619-627.

        Galland L. Impaired essential fatty acid metabolism in latent tetany [J]. Magnesium-

        Hagve T A, Christophersen, B O, Dannevig B H. Desaturation and Chain Elongation of Essential Fatty Acids in Isolated Liver Cells from Rat and Rainbow Trout [J]. Lipids, 1986, 21: 202-

        Sellner P A, Hazel J R. Incorporation of Polyunsaturated Fatty Acids into Lipids of Rainbow Trout Hepatocytes [J]. Am J Physiol, 1982, 243: 223-

        Hagar A F, Hazel J R. Changes in desaturase activity and the fatty acid composition of microsomal membranes from liver tissue of thermally-acclimating rainbow trout [J]. J Comp Physiol -

        Tocher D R, Fonseca-Madrigal J, Dick J R, et al. Effects of water temperature and diet containing palm oil on fatty acid desaturation and oxidation in hepatocytes and intestinal enterocytes of rainbow trout (Onchor-hynchus mykiss) [J]. Comp Biochem Physiol, 2004, 137B: 49-

        Vagner M, Robin J H, Zambonino Infante J L, et al. Combined effects of dietary HUFA level and temperature on sea bass (Dicentrarchus labrax) larvae development [J]. Aquaculture, 2007, 266: 179-

        Vagner M, Zambonino Infante J L, Robin J H, et al. fluence European sea bass (Dicentrarchus labrax) juvenile metabolism by a nutritional conditioning during larval stage [J]. Aquaculture, 2007, 267: 165-

        Somerville C. Direct tests of the role of membrane lipid composition in low-temperature induced photoinhibition and chilling sensitivity in plants and cyanobacteria [J]. Proc Natl Acad Sci U SA, 1995, 92: 6215-

        Skalli A, Robin J H, Le Bayon N, et al. Impact of essential fatty acid deficiency on tissues’ fatty acid composition of European sea bass (Dicentrarchus labrax) [J]. Aquaculture, 2006, 255: 223-

        Sheridan M A, Allen W V, Kerstetter T H. Changes in the fatty acid composition of Steelhead Trout(Salmo gairdnerii Richardson) associated with parr-smolt transformation [J]. Comp Biochem Physiol, 1985, 80B: 671-

        Li H O, Yamada J. Changes of the fatty acid composition in smolts of masu salmon (Oncorhynchus masou) associated with desmoltication and seawater transfer [J]. Comp Bio­chem Physiol, 1992, 103A: 221-

        Sarkar M A, Yamamoto Y H, YutakaSarker M S A, et al. Influences of low salinity and dietary fatty acids on fatty acid composition and fatty acid desaturase and elongase expres­sion in red sea bream Pagrus major [J]. Fish Sci, 2011, 77: 385-

        Kheriji S, El Cafsi M, Masmoudi W, et al. Salinity and temperature effects on the lipid composition of mullet sea fry (Mugil cephalus, Linne, 1758) [J]. Aquacult Int, 2003, 11: 571-

        Xu J, Yan B, Teng Y, Lou G, et al. Analysis of nutrient composition and fatty acid profiles of Japanese sea bass Lateolabrax japonicus (Cuvier) reared in seawater and freshwater [J]. J Food Comps Anal, 2010, 23: 401-

        Hunt A O, Oxkan F E, Engin K, et al. The effects of freshwater rearing on the whole body and muscle tissue fatty acid profile of the European sea bass (Dicentrarchus labrax) [J]. Aquacult Int, 2011, 19: 51-

        Tocher D R. Fatty acid requirements in ontogeny of marine and freshwater fish [J]. Aquacult Res, 2010, 41: 717-

        J, Pineda-Delgado D, Martinez-Palacios C, et al. Effect of salinity on the biosynthesis of n-3 long-chain polyunsaturated fatty acids in silverside Chirostoma estor [J]. Fish Phsiol Biochem, 2012, 38: 1047-

        Cengiz M, Ünlü E, Bashan M, et al. Effect of seasonal variations on the fatty acid composition of total lipid pho­spho­lipid and triacylglicerol in the dorsal muscle of Meso­po­tamian Catfish (Silurus triostegus) in Tigris River (Turkey) [J]. Turkish J Fish Aquat Sci, 2012, 12: 33-

        Calabretti A, Cateni F, Procida G, et al. Influence of environmental temperature on composition of lipids in edible flesh of rainbow trout (Oncorhynchus mykiss) [J]. J Sci Food Agriculture, 2003, 83 (14): 1493-

        Guler G O, Aktumsek A, Citil O B, et al. Seasonal variations on total fatty acid composition of fillets of zander (Sander lucioperca) in Beysehir Lake (Turkey) [J]. Food Chem, 2007, 103: 1241-

        Kalyoncu L, Kissal S, Aktumsek A. Seasonal changes in the total fatty acid composition of Vimba, Vimba vimba tenella (Nordmann, 1840) in Egirdir Lake, Turkey [J]. Food Chem, 2009, 116(3): 728-

        Tocher D R, Bell J G, Henderson R J, et al. The effect of dietary linseed and rapeseed oils on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergo­ing parr-smolt transformationFish Physiol Biochem, 2000, 23: 59-

        Nakamura M T, Nara T Y. Essential fatty acid synthesis and its regulation in mammals [J]. Prostaglandins, Leukotrienes Essential Fatty Acids, 2003, 68, 145-

        Nakamura M T, Nara T Y. Gene regulation of mammalian desaturases [J]. Biochem Soc Trans, 2002, 30 (6): 1076-

        Shimomura I, Shimano H, Korn B S, et al. Nuclear sterol regulatory element-binding proteins activate genes respon­sible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver [J]. J Biol Chem, 1998, 273: 35299-

        Louet J F, Chatelain F, Decaux J F, et al. Long-chain fatty acids regulate liver carnitine palmitoyl transferaseI gene (L-CPT I) expression through a peroxisome-proliferator- activated receptor alpha (PPARalpha)-independent pathway [J]. J Biol Chem, 2001, 354: 189-

        Reddy J K, Goel S K, Nemali M R, et al. Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators [J]. Proc Natl Acad Sci, 1986, 83: 1747-

        Aldridge T C, Tugwood J D, Green S. Identification and characterization of DNA elements implicated in the regula­tion of CYP4A1 transcription [J]. J Biol Chem, 1995, 306: 473-

        He W S, Nara T Y, Nakamura M T. Delayed in duction of Δ6 and Δ5 desaturases by a peroxisome proliferators [J]. Biochem Biophys Res Commun, 2002, 299: 832-

        Tang C, Cho H P, Nakamura M T, et al. Regulation of human D-6 desaturase gene transcription: identification of a func­tional direct repeta-1 element [J]. Lipid Res, 2003, 44: 686-

        Brenner R R. Nutritional and hormonal factors influencing desaturation of essential fatty acids [J]. Prog Lipid Res, 1981, 20: 41-

        郑一军环境盐度和饲料脂类成分对黄斑蓝子鱼的生长性能和生物合成能力的影响汕头: 汕头大学

        Jump D B. The biochemistry of n-3 polyunsaturated fatty acids [J]. Biol Chem, 2002, 277: 8755-

        Jump D B, Thelen A, Ren B, et al. Multiple mechanisms for polyunsaturated fatty acid regulation of hepatic gene transcription, Prostaglandins Leukot Essent [J]. Fat Acids, 1999, 60: 345-

        Alan R, Saltiel C, Ronald K. Insulin signalling and the regulation of glucose and lipid metabolism [J]. Nature, 2001, 414: 799-

        Morais S, Pratoomyot J, Bell J G, et al. Family-specific responses to dietary fish oil replacement by vegetable oil in Atlantic salmon: microarry analysis of liver transcriptome [C]//International Symposium on Fish Nutrition And Feeding. Qingdao: The Ocean University of China, 2010.

        Morais S, Pratoomyot J, Taggart J B, et al. Genotype-specific responses in Atlantic salmon (Salmo salar) subject to dietary fish oil replacement by vegetable oil: a liver transcriptomic analysis[J]. BMC Gen, 2011, 12: 255.

    网友评论
    网友评论
    分享到微博
    发 布
分享
文章指标
  • 点击次数:2143
  • 下载次数: 669
  • HTML阅读次数: 0
  • 引用次数: 0
历史
  • 在线发布日期: 2013-04-08
文章二维码