锯缘青蟹血蓝蛋白抑菌活性及其作用靶标
作者:
作者单位:

汕头大学 理学院 生物学系, 广东省海洋生物技术重点实验室, 广东 汕头 515063

作者简介:

陈传道(1989−), 男, 硕士研究生, 主要从事无脊椎动物分子免疫学研究. E-mail: chen_chuandao@boffin.com.cn

中图分类号:

S945

基金项目:

国家自然科学基金项目(30871939, 31072237); 教育部新世纪优秀人才支持计划项目(NCET-11-0922); 广东省自然科学基金重点项目(10251503101000002); 广东省高等学校高层次人才项目(2011); 广东省高等学校科技创新重点项目(2012CXZD0025).


Investigation of the antimicrobial properties of mud crab Scylla serrata hemocyanin and its binding targets to pathogens
Author:
Affiliation:

Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou 515063, China

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    摘要:

    等细菌具有抑菌活性的抑菌活性可被大肠杆菌(Outer membrane protein, Omp)、与对照组相比<0.01)

    Abstract:

    Recent research suggests hemocyanin acts as an immunologically multi-functional protein in invertebrates. However, little is known about the antibacterial activity of hemocyanin. We evaluated the antibacterial activity of this hemocyanin and its binding target to pathogens using antibacterial and antibacterial inhibition assays. The hemocyanin exhibited antibacterial activity against K12. This activity was completely or partly inhibited by the outer membrane proteins of hemocyanin against K12 Omp-deletion mutants of OmpW was significantly lower than that of the control. Together, our results suggest that hemocyanin exhibits antibacterial activity by binding to a range of outer membrane proteins

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陈传道,刘瑶,黄玉活,严芳,伦镜盛,章跃陵.锯缘青蟹血蓝蛋白抑菌活性及其作用靶标[J].中国水产科学,2013,20(3):644-649
CHEN Chuandao, LIU Yao, HUANG Yuhuo, YAN Fang, LUN Jingsheng, ZHANG Yueling. Investigation of the antimicrobial properties of mud crab Scylla serrata hemocyanin and its binding targets to pathogens[J]. Journal of Fishery Sciences of China,2013,20(3):644-649

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  • 在线发布日期: 2013-05-30
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