Glutaredoxins (Grxs) are ubiquitous small disulfide oxidoreductases that play a crucial role in response to oxidative stress and regulation of growth and development. Howeverthe structural features and function of Grxs in marine invertebrates are still unknown compared with those of and xamined tissueswhich is consistent with the viewpoint that the hepatopancreas and gills are the most important organs in the host immune defense and detoxification systems. Bacterial challenging significantly up-regulated, transcripts may be associated with increasing reactive oxygen species (ROS) that is generated after apathogen challenge. hepatopancreasresults showed an obviously concentration-dependent increase. The highest expression level for (34.87 fold) in hepatopancreas was observed after 80 μg/L Cd exposure for 30 days. More or less compatible transcriptional modulation patterns were also experienced in several organismsCd can induce oxidative stress by increasing levels of ROS. The increase in V. philippinarumcould be induced by the production of ROS generated by Cdsuggesting aGrx protective role in the defense against oxidative stress. mRNA decreased sharply (0.03 fold at 0.8 and 80 μg/L Cd were increased significantly (4.77 fold at 0.8 μg/L Cds gene expression highlighted the fact that these isoenzymes probably played divergent physiological roles during the detoxification of Cd in hemocytes of . Future studies should explore the diverse expression patterns of after exposure to Cd. In conclusionthese results suggested that VpGrx1 and VpGrx2 may be important proteins involved in host immune defense and heavy metal detoxification.