The growth hormone receptor (Andrias davidianus), based on a partial sequence from the transcriptome database. The full-length cDNA was 2992 bp, containing an open reading frame of 1812bpthat encoded a deduced protein of 604 amino acids with one conserved FGEFS domain and two BOX domains. System evolution analysis showed that Chinese salamander GHR had the highest similarity with the GHR proteins from amphibians ), and the lowest with mammals (). The expression pattern of in different tissues was evaluated. Its expression level was the highest in the liver, followed by the muscle, pituitary gland, kidney and gonads; its expression was very low in other tissues. The expression level of in the testis was higher at the early stage, and then decreased as the testes developed. However, the expression level increased as the ovary developed. Furthermore, transient treatment with 17α-Methyltestosterone (MT) and letrozole (LE) had different effects on the expression of in the brain and ovary was increased by MT treatment but decreased by LE treatment. Our results indicated that GHR may play an important role in gonadal development, and was affected differently by MT and LE treatment.